Divergent roles of immune cells and their mediators in pain

R Raoof, HLDM Willemen, N Eijkelkamp - Rheumatology, 2018 - academic.oup.com
… tissue damage, infiltrating or resident peripheral immune cells … In some neuropathic pain
models mechanical allodynia is … of neuropathic pain and is rescued by adoptive transfer of CD4 …

Gut microbiota influences neuropathic pain through modulating proinflammatory and anti-inflammatory T cells

W Ding, Z You, Q Chen, L Yang, J Doheny… - Anesthesia & …, 2021 - journals.lww.com
… , as demonstrated by dampened mechanical allodynia and … Adoptive transfer of these T cells
alleviated the severity of … on the innate immune system and adaptive immune system are not …

[HTML][HTML] Differential effects of regulatory T cells in the meninges and spinal cord of male and female mice with neuropathic pain

NT Fiore, BA Keating, Y Chen, SI Williams… - Cells, 2023 - mdpi.com
… In this study, we utilised intrathecal adoptive transfer of … mechanical allodynia only in male
mice, and inflammatory and … in the mouse brain, potentiating neurological recovery after an …

[HTML][HTML] Sex-specific B cell and anti-myelin autoantibody response after peripheral nerve injury

HJ Lee, AG Remacle, SK Hullugundi… - Frontiers in Cellular …, 2022 - frontiersin.org
… of sexual dimorphism in adaptive immune regulation of neuropathic pain is necessary to …
B cell and splenocyte adoptive transfer, which potentiate mechanical allodynia in males post…

[HTML][HTML] The Antinociceptive Potential of Camellia japonica Leaf Extract, (−)-Epicatechin, and Rutin against Chronic Constriction Injury-Induced Neuropathic Pain in …

EY Lim, C Lee, YT Kim - Antioxidants, 2022 - mdpi.com
… of neuropathic pain involves the peripheral immune system … and further potentiate
neuropathic pain. Inflammatory … attenuated mechanical allodynia in neuropathic pain models […

The neuroimmunology of chronic pain: from rodents to humans

PM Grace, VL Tawfik, CI Svensson… - Journal of …, 2021 - Soc Neuroscience
… to pain (pain OR hyperalgesia OR allodynic OR allodynia OR … chronic pain after injury is
activation of the immune system. … neuropathic pain in preclinical models. For example, using a …

[HTML][HTML] … into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries

B Du, YQ Ding, X Xiao, HY Ren, BY Su… - Journal of …, 2018 - Springer
… To provide the rationality of the mSNI neuropathic pain model … For lymphadenectomy to
LLNs and CLNs, we adopted the … cells among the immune cells in the spleens after peripheral

[HTML][HTML] Immune dysregulation in patients with carpal tunnel syndrome

G Moalem-Taylor, B Baharuddin, B Bennett… - Scientific reports, 2017 - nature.com
… symptoms including mechanical hyperalgesia and cold allodynia 21 . The … neuropathic
pain symptoms as it is upregulated in injured nerves and potentiates pain transmission

[HTML][HTML] Peripheral Beta-2 Adrenergic Receptors Mediate the Sympathetic Efferent Activation from Central Nervous System to Splenocytes in a Mouse Model of …

S Yamashita, N Dozono, S Tobori, K Nagayasu… - International Journal of …, 2023 - mdpi.com
… Abnormalities in the peripheral immune system are involved in the pathophysiology of … of
neuropathic pain, the adoptive transfer of splenocytes derived from chronic constriction injury (…

[HTML][HTML] Repetitive transcranial magnetic stimulation regulates neuroinflammation in neuropathic pain

YW Bai, QH Yang, PJ Chen, XQ Wang - Frontiers in Immunology, 2023 - frontiersin.org
… various immune cells near or within peripheral nerves. … IL-1β or lipopolysaccharide on
long-term potentiation (57–59)… and astrocytes, resulting in chronic allodynia development (71–76). …